Fibrinolysis; its mechanism and significance.
نویسندگان
چکیده
INTRODUCTION T HE BIOLOGIC processes that produce a gross physical change have always attracted much interest. The transformation of fluid blood to solid clot, for instance, has been the subject of experiment and discussion the amount of which seems disproportionate to its fundamental physiologic importance. There is, however , a converse to this process of coagulation which, though equally obvious in its result, has been comparatively neglected, possibly because in its extreme form it occurs only rarely and with apparent irregularity. This is the phenomenon of fibrinolysis or dissolution of blood clot that, though normally slow, may occur with great rapidity under certain conditions. Though there has been relatively little work on this subject recent developments have made it possible to appreciate part of the mechanism that underlies it, and to realize that factors are involved which are of basic importance. It is apparent also that the process of fibrinolysis is linked with other subjects previously without obvious association, and this paper, though it cannot claim to be a complete review, is presented as an attempt to assemble relevant information, and to relate it to some observations of our own. DEFINITION For the purpose of this communication fibrinolysis is taken to mean the aseptic dissolution of fibrin brought about by the direct action of a mechanism existing in normal blood. Usually dissolution may take days or weeks to complete, but may be so accelerated as a result of natural changes occurring in the living subject or of experimental procedures as to occur within a few hours or minutes. This increased activity is the main subject dealt with, and though a particular set of factors have been studied as being apparently those mainly responsible, it is recognized that others may be involved.
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عنوان ژورنال:
- Blood
دوره 3 10 شماره
صفحات -
تاریخ انتشار 1948